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      >>研究成果

主持人姓名

陳柏熹

單位

精神科

職稱

主治醫師

連絡電話

5190

e-mail addresschenps@mail.ncku.edu.tw

研究主題

中文:神經膠細胞與精神神經免疫學

英文:Glia cell and Psychoneuroimmunology

研究方向

Many studies have established the routes by which the immune and central nervous systems communicate. This network of connections permits the central nervous systems to regulate the immune system through both neuroendocrine and neuronal pathways. In turn, the immune system signals the central nervous systems through neuronal and humoral routes, via immune mediators and cytokines. Now we use primary culture to investigate the role of glial cells (astrocyte and microglia) in these interactions.

 

 

 

 

 

 

 

 

研究成果

1.          Peng GS, Li G, Tzeng NS, Chen PS, Chuang DM, Hsu YD, Yang S, Hong JS:  Valproate pretreatment protects dopaminergic neurons from LPS-induced neurotoxicity in rat primary midbrain cultures: role of microglia. Brain Res Mol Brain Res. 2005; 24:162-169.

2.           Chen PS, Peng GS, Li G, Yang S, Lu RB, Gean PW, Chuang DM, Hong JS:  Valproate Induces GDNF in Astrocyte and Exhibits Neurotrophic and Neuroprotective Effects in Midbrain Dopaminergic Neurons. Molecular Psychiatry (revised).

3.           Chen PS, Wang CC, Bortner CD, Pang H, Wu X, Peng GS, Lo YC, Lu RB, Gean PW, Chuang DM, Hong JS: Valproic Acid Induces Microglial Apoptosis and Attenuates Lipopolysaccharide-induced Dopaminergic Neurotoxicity. Glia (revised).

4.           Yang S, Yang J, Yang Z, Chen PS, Fraser A, Zhang W, Pang H, Gao X, Wilson B, Hong JS, Block ML: PACAP38 and PACAP4-6 are neuroprotective through inhibition of HADPH oxidase: potent regulators of microglia-mediated oxidative stress. JPECT (submitted).

5.Kim HJ, Row M, Ren M, Hong JS, Chen PS, ChuangDM: HDAC Inhibitors Valproate and Butyrate show Anti-inflammatory and Neuroprotective Effects in a Rat Permanent Ischemic Model of Stroke. Journal of Neuroscience (submitted).

 


 

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